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Let's talk about CBD with Dr Call MD

Nature’s Ultra (NU): Thank you, Dr. Call for your willingness to visit with us today

Dr. Call: You are welcome, happy to be here.  


NU: So…Dr. Call, CBD is a hot topic right now. What has caught your attention?

Dr. Call: Yes, it is a hot topic, indeed. It seems like it’s in the news almost every day. I am seeing news feeds about CBD oil all of the time. People are excited about it.  Many people say they are benefitting from it. I’m getting emails from local coalitions about it. When I hear about this sort of stuff, the scientist in me has questions, and I turn to the published data. I also look at what experts are saying. As I have done this, I have been overall impressed with what I have found so far.


NU: Can you give some examples?

Dr. Call:  Sure, so… one of the most recent papers that I came across was a review article by Dr. Crippa and colleagues that discusses the therapeutic potential of CBD. It was published this year in the journal called Frontiers in Immunology. In it, they review the studies that have shown CBD to have anxiolytic, antipsychotic, and neuroprotective properties. They also reviewed the investigations that cover its potential use in epilepsy, substance abuse, substance dependence, schizophrenia, social phobia, PTSD, depression, sleep disorders, Parkinson’s disease, and others.


NU: Wow, that’s a lot you just covered. I don’t know where to begin with all of that.

Dr. Call: I know, there’s a lot going on with this topic. Last I checked, PubMed (a trusted source for medial journal publications) was showing 281 new publications on canibidiol (CBD) in just 2018 alone. There is a ton of activity right now. Many papers being published and many studies underway. It was back in 1963 that Professor Raphael Mechoulam first discovered the exact chemical structure of CBD. Since then, many studies have been done but the investigation recently has really ramped up.


NU:  Ok, well, I know you don’t have time today to cover all of those topics, but could you explain a few things that have stood out in your reviewing of the studies?

Dr. Call:  Sure. I think the first thing that comes to mind is the safety profile of CBD. I have read through many studies and none of them have reported significant side effects. In fact, many researchers comment on the wide therapeutic window that CBD has.


NU: What do you mean by “wide therapeutic window?”

Dr. Call: I mean that they are seeing a wide range of doses used in the studies without significant side effects. That’s a good thing.  No one likes side effects.


NU: Very true. What else has stood out?

Dr. Call:  Well…One of the first studies I read on CBD that impressed me was a study by Dr. Zuardi and colleagues, published in the Journal of Psychopharmacology. Their study took healthy volunteers and put them through a simulated, public-speaking test. Heart rate, blood pressure, and skin conductance were all recorded. Volunteers were given either CBD, ipsapirone (anti-anxiety and anti-depressant medication), or diazepam (anti-anxiety medication). Their findings showed that the CBD effectively reduced anxiety, just as the other two medications did. I found that to be very impressive.


NU: So the study suggested that the CBD reduced their anxiety like the diazepam did?

Dr. Call: Yes, both the CBD and diazepam reduced anxiety in the study.


NU: Impressive. What else?

Dr. Call: There are some interesting animal studies on the antipsychotic effects of CBD. Pretty impressive. It is likely that human studies are underway now based on the impressive effects that were seen in the animal studies. The same goes for studies regarding sleep, anti-inflammation, chronic pain, and more. These are notable pilot studies that hopefully will be repeated in humans so we can know more.


NU: Yes, hopefully. That is exciting. Is there anything you have come across that has concerned you?

Dr. Call: An issue I have come across is dosing. Different studies have used different doses and thus I imagine it is very hard for someone to know what dose is right for them and their needs. I’m guessing that people have to adjust doses based on effect and figure it out on their own. Hopefully future studies will shed light on that topic. Luckily, it appears to be well tolerated at a wide variety of doses.


NU: Yes, hopefully the many studies that are underway will help us to understand better the many benefits of having CBD in our lives. So exciting. Any other thoughts or concerns Dr. Call?

Dr. Call: Well, another thing is that it seems like there has been a rare, but serious, problem in the CBD industry because there have been products sold by shady companies that may not have been what the consumer thought they were. People have gotten sick and injured from buying stuff that they thought was CBD and it really wasn’t.


NU: Yes, we agree. At Nature’s Ultra we sell industrial hemp-derived pharmaceutical-grade CBD. We have all of our products 3rd party tested before they ship out to the consumer to assure that it is pure and free from contaminants. We have premium quality CBD.

Dr. Call: That is very good.


NU: Thanks so much for your time today, Dr. Call. I know you’re busy, so again, thank you so much for spending a minute to chat with us. We hope you’ll be able to stop by again.

Dr. Call: Thanks, will do.